Nature Paper Proposes Regulatory Framework for Non-Deterministic Clinical AI and Agentic Systems

Summary

A new paper published in npj Digital Medicine introduces the concept of "Unconfined Non-Deterministic Clinical Software" (UNDCS) as a regulatory category for AI systems used in healthcare, particularly addressing the challenges posed by agentic AI and large language models in clinical settings. The authors — Caitlyn Tan, Dinesh Visva Gunasekeran, and colleagues including Tien Yin Wong — argue that existing regulatory frameworks are insufficient for AI systems that produce variable outputs and op