Evo 2: A 40B-Parameter Foundation Model for Genome Modeling Across All Domains of Life

Summary

Researchers have published Evo 2, a large-scale genomic foundation model available in 7B and 40B parameter variants, in Nature. The model is trained on DNA sequences spanning all domains of life — prokaryotic and eukaryotic — and demonstrates strong zero-shot prediction capabilities for tasks such as human variant effect prediction. Evo 2 builds on the earlier Evo 1 model (published in Science in 2024) and represents a significant step in applying transformer-scale sequence modeling to computati